Hey there,
I don't think the TF will behave different than any other delay pedal. After all, what's causing the – let's call it special sound hehe – is the distortion. The delay repeats mix with the dry signal and get distorted together … more distortion = worse (could work with low gain, though). Same principle happens when you put a harmonizer in front of distortion. It sound like ass …
Best leave it in the loop if you have one. Otherwise, well, you're basically screwed when you want high gain and delay …
