Depending on the preamp, that's how you want to run the setup. Some preamps that have other FX allow you to change the order of FX (including FX loop) that will allow for even more tonal flexibility. The other thing to keep in mind is how the preamp deals with the FX loop…when you turn it on and off, does it cut off the return path or does it allow the natural decay of time based FX on the outboard gear attached to the preamp? Those are things to consider. I run my eclipse thru my pre and get that natural decay, but that's also how my pre is setup, plus I can change the order of built in FX and the FX loop, besides the send/return levels and mix levels of pre to loop.