It's just a Digitech Whammy ^OCT setting, and you pump the treadle with your pick attacks. Most are quick glides, with the occasional expressive slow glide to +1 Octave. You could replicate that sound with any number of PitchFactor algorithms.  There were some factory presets in the "20's" like this, as I recall.  The most obvious first choice would be PitchFlex, along with an expression pedal.

I've overwritten nearly all of my PitchFactor factory presets, but this should get you started.  The Delay A, Delay B, and Speed / Scale settings are optional, but you can use them with the FLEX switch in Play mode (instead of an expression pedal).  Not quite as expressive for this song's solo, but close.  Tap the switch with your pick attacks, and mute the note just about when you release the switch.

LikeABrock

Mix = WET:100

Pitch Mix = A10+B10

Pitch A = A(H): UNISN

Pitch B = B(H): UNISN

Delay A = H(T): 0.25S

Delay B = T(H): 0.05S

(encoder) = PITCHFLX / TMP OFF

Depth / Key = FLT:  0

Speed / Scale = SHAP:  5

Xnob = A(T): +1oct

Ynob = B(T): +1oct

Now just play like Tom Morello.