Boost gain as needed.  I often leave these highly resonant Programs on the low side.  The peaks can suddenly jump ‘into the red’, and cause problems.

I just try to come close to Zappa’s array of custom gear.  An important component is the Systech Harmonic Energizer.  Mine (the Overdrive version) is showing its age.  I’ve often considered the Godlyke Triskelion; just to see how close it comes to that unique vintage pedal.

One nice addition is sweeping the narrow center frequency with an expression pedal.  Something I always wanted to ‘hack’ into the original.