WhWhether it's with Bogner Shiva combo, Fuchs combo, Mesa Boogie Lone Star/Lone Star Special combos: I put my M-Factor and T-Factor in the FX loops, putiing any modulation device before delay/time altering device. Delaying & then modulating a signal (for me) bends and mutates the basic signal a bit too much. Most studios I've worked in do that as well, unless you're looking for an unusual sound. Let your ears and taste buds dictate your preference(s).
